The riff: Said in astonishment by Crow as one of the sky pilots leans in on Commando Cody.
The explanation: It would seem that the phrase “zactly” or “zactlies” is a reference to an old joke about “zactly breath.” Basically, it describes someone with breath so bad, it smells “zactly” like their anus. Likewise, “zactly disease” would be the debilitating condition of having “yo face look zactly like yo ass.” I think we can all agree that these are dread diseases that would condemn the sufferer to a lifetime alone.
Novelty factor: Definitely no idea. I like how with one riff, these guys are discussing advanced scientific theory, and with the next they’re joking that someone’s breath smells like butts. BUTTS I SAY.