The episode: “Samson vs. the Vampire Women,” ep. 624
The explanation: “Capitol Critters” was a short-lived animated TV series that was broadcast on ABC for a few months in early 1992. The main character was a mouse named Max who lived with a group of mice, cockroaches and rats in the walls of the White House in Washington D.C. after his entire Nebraska family is murdered by exterminators with poison gas in the opening minutes of the series. Thus begins the most macabre opening to a primetime animated series of all time.
Novelty factor: I am blown away that I’ve never heard of this before, but I guess it makes sense because only seven of the original 13 episodes were even broadcast by ABC. What the hell were they thinking with having the main character’s family murdered within the first four minutes?